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BDBM50188884 CHEMBL212441::rac-8-[1-(4-fluoro-phenyl)-cyclohexyl]-4-p-tolyl-2,8-diaza-spiro[4.5]decan-1-one

SMILES: Cc1ccc(cc1)C1CNC(=O)C11CCN(CC1)C1(CCCCC1)c1ccc(F)cc1

InChI Key: InChIKey=VCPCEUAIERDWJJ-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50188884   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycine transporter 1


(Homo sapiens (Human))
BDBM50188884
PNG
(CHEMBL212441 | rac-8-[1-(4-fluoro-phenyl)-cyclohex...)
Show SMILES Cc1ccc(cc1)C1CNC(=O)C11CCN(CC1)C1(CCCCC1)c1ccc(F)cc1
Show InChI InChI=1S/C27H33FN2O/c1-20-5-7-21(8-6-20)24-19-29-25(31)26(24)15-17-30(18-16-26)27(13-3-2-4-14-27)22-9-11-23(28)12-10-22/h5-12,24H,2-4,13-19H2,1H3,(H,29,31)
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Similars

Article
PubMed
n/an/an/an/a 73n/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]glycine uptake at GlyT1


Bioorg Med Chem Lett 16: 4321-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.063
BindingDB Entry DOI: 10.7270/Q2P26ZXG
More data for this
Ligand-Target Pair