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BDBM50188935 5-(2-methylamino-pyrimidin-4-yl)-thiophene-2-carboxylic acid [2-(4-sulfamoyl-phenyl)-ethyl]-amide::CHEMBL213633

SMILES: CNc1nccc(n1)-c1ccc(s1)C(=O)NCCc1ccc(cc1)S(N)(=O)=O

InChI Key: InChIKey=RPPLTSGMKAPGNM-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50188935   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase AKT


(Homo sapiens (Human))
BDBM50188935
PNG
(5-(2-methylamino-pyrimidin-4-yl)-thiophene-2-carbo...)
Show SMILES CNc1nccc(n1)-c1ccc(s1)C(=O)NCCc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C18H19N5O3S2/c1-20-18-22-11-9-14(23-18)15-6-7-16(27-15)17(24)21-10-8-12-2-4-13(5-3-12)28(19,25)26/h2-7,9,11H,8,10H2,1H3,(H,21,24)(H2,19,25,26)(H,20,22,23)
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PC sid
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Patents


Similars

Article
PubMed
n/an/a 1.90E+4n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of AKT3 in presence of 0.2 uM ATP


Bioorg Med Chem Lett 16: 4163-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.092
BindingDB Entry DOI: 10.7270/Q24M945C
More data for this
Ligand-Target Pair