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BDBM50189304 CHEMBL3827991

SMILES: CCOC(=O)c1cc(C(=O)\C=C\c2ccc(Br)cc2)n2ccc(OC)cc12

InChI Key: InChIKey=DZAIAPALPTXITL-RMKNXTFCSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50189304   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50189304
PNG
(CHEMBL3827991)
Show SMILES CCOC(=O)c1cc(C(=O)\C=C\c2ccc(Br)cc2)n2ccc(OC)cc12
Show InChI InChI=1S/C21H18BrNO4/c1-3-27-21(25)17-13-19(23-11-10-16(26-2)12-18(17)23)20(24)9-6-14-4-7-15(22)8-5-14/h4-13H,3H2,1-2H3/b9-6+
PDB
MMDB

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PC sid
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Similars

Article
PubMed
n/an/a 602n/an/an/an/an/an/a



Alexandru Ioan Cuza University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant farnesyltransferase using farnesylpyrophosphate and dansyl-GCVLS as substrate measured for 15 mins by fluorescence as...


Bioorg Med Chem Lett 26: 3730-4 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.074
BindingDB Entry DOI: 10.7270/Q2DR2XFP
More data for this
Ligand-Target Pair