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BDBM50190214 3-chloro-N-[8-chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,e][1,4]diazepin-5-yl]-benzamide::CHEMBL213084

SMILES: CN1CCN(CC1)C1=Nc2cc(Cl)ccc2N(NC(=O)c2cccc(Cl)c2)c2ccccc12

InChI Key: InChIKey=CVACHCAWLODKMA-UHFFFAOYSA-N

Data: 2 KI

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50190214   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50190214
PNG
(3-chloro-N-[8-chloro-11-(4-methyl-piperazin-1-yl)-...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2N(NC(=O)c2cccc(Cl)c2)c2ccccc12
Show InChI InChI=1S/C25H23Cl2N5O/c1-30-11-13-31(14-12-30)24-20-7-2-3-8-22(20)32(23-10-9-19(27)16-21(23)28-24)29-25(33)17-5-4-6-18(26)15-17/h2-10,15-16H,11-14H2,1H3,(H,29,33)
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PC cid
PC sid
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Similars

Article
PubMed
4n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells


Bioorg Med Chem Lett 16: 4543-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.022
BindingDB Entry DOI: 10.7270/Q2GT5MSW
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50190214
PNG
(3-chloro-N-[8-chloro-11-(4-methyl-piperazin-1-yl)-...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2N(NC(=O)c2cccc(Cl)c2)c2ccccc12
Show InChI InChI=1S/C25H23Cl2N5O/c1-30-11-13-31(14-12-30)24-20-7-2-3-8-22(20)32(23-10-9-19(27)16-21(23)28-24)29-25(33)17-5-4-6-18(26)15-17/h2-10,15-16H,11-14H2,1H3,(H,29,33)
PDB

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UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
181n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]methylspiperone from human dopamine D2 receptor expressed in CHO cells


Bioorg Med Chem Lett 16: 4543-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.022
BindingDB Entry DOI: 10.7270/Q2GT5MSW
More data for this
Ligand-Target Pair