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BDBM50190459 CHEMBL377986::N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-[4-(4-methoxyphenyl)butyl]-guanidine

SMILES: COc1ccc(CCCCN=C(N)NC(=O)c2nc(Cl)c(N)nc2N)cc1

InChI Key: InChIKey=UVGRAPSNRCDSEO-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50190459   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190459
PNG
(CHEMBL377986 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES COc1ccc(CCCCN=C(N)NC(=O)c2nc(Cl)c(N)nc2N)cc1
Show InChI InChI=1S/C17H22ClN7O2/c1-27-11-7-5-10(6-8-11)4-2-3-9-22-17(21)25-16(26)12-14(19)24-15(20)13(18)23-12/h5-8H,2-4,9H2,1H3,(H4,19,20,24)(H3,21,22,25,26)
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Similars

Article
PubMed
n/an/a 15n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


J Med Chem 49: 4098-115 (2006)


Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH
More data for this
Ligand-Target Pair