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BDBM50190460 CHEMBL211773::N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-[2-(4-methoxybenzyloxy)ethyl]-guanidine

SMILES: COc1ccc(COCCN=C(N)NC(=O)c2nc(Cl)c(N)nc2N)cc1

InChI Key: InChIKey=XSRGEJYIBDQBJD-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50190460   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190460
PNG
(CHEMBL211773 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES COc1ccc(COCCN=C(N)NC(=O)c2nc(Cl)c(N)nc2N)cc1
Show InChI InChI=1S/C16H20ClN7O3/c1-26-10-4-2-9(3-5-10)8-27-7-6-21-16(20)24-15(25)11-13(18)23-14(19)12(17)22-11/h2-5H,6-8H2,1H3,(H4,18,19,23)(H3,20,21,24,25)
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Similars

Article
PubMed
n/an/a 41n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


J Med Chem 49: 4098-115 (2006)


Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH
More data for this
Ligand-Target Pair