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BDBM50190465 1-(4-(4-aminophenyl)butyl)-3-(3,5-diamino-2-chloropyrazine-6-carbonyl)guanidine::CHEMBL212410

SMILES: NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(N)cc1

InChI Key: InChIKey=KOKWQVJPVOHNKZ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50190465   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190465
PNG
(1-(4-(4-aminophenyl)butyl)-3-(3,5-diamino-2-chloro...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(N)cc1
Show InChI InChI=1S/C16H21ClN8O/c17-12-14(20)24-13(19)11(23-12)15(26)25-16(21)22-8-2-1-3-9-4-6-10(18)7-5-9/h4-7H,1-3,8,18H2,(H4,19,20,24)(H3,21,22,25,26)
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Article
PubMed
n/an/a 21n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


J Med Chem 49: 4098-115 (2006)


Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH
More data for this
Ligand-Target Pair