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BDBM50190482 CHEMBL210967::N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-[3-(4-methoxyphenyl)propyl]-guanidine

SMILES: COc1ccc(CCCN=C(N)NC(=O)c2nc(Cl)c(N)nc2N)cc1

InChI Key: InChIKey=MNUFMYQWEVSFMV-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50190482   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190482
PNG
(CHEMBL210967 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES COc1ccc(CCCN=C(N)NC(=O)c2nc(Cl)c(N)nc2N)cc1
Show InChI InChI=1S/C16H20ClN7O2/c1-26-10-6-4-9(5-7-10)3-2-8-21-16(20)24-15(25)11-13(18)23-14(19)12(17)22-11/h4-7H,2-3,8H2,1H3,(H4,18,19,23)(H3,20,21,24,25)
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Similars

Article
PubMed
n/an/a 124n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


J Med Chem 49: 4098-115 (2006)


Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH
More data for this
Ligand-Target Pair