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BDBM50190491 CHEMBL210966::N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-hexylguanidine

SMILES: CCCCCCN=C(N)NC(=O)c1nc(Cl)c(N)nc1N

InChI Key: InChIKey=ACVAUATXKGKIKY-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50190491   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190491
PNG
(CHEMBL210966 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES CCCCCCN=C(N)NC(=O)c1nc(Cl)c(N)nc1N
Show InChI InChI=1S/C12H20ClN7O/c1-2-3-4-5-6-17-12(16)20-11(21)7-9(14)19-10(15)8(13)18-7/h2-6H2,1H3,(H4,14,15,19)(H3,16,17,20,21)
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Article
PubMed
n/an/a 87n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


J Med Chem 49: 4098-115 (2006)


Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH
More data for this
Ligand-Target Pair