BDBM50190513 (RS)-1-butyl-3-(cyclohexylmethyl)-9-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methyl)-1,4,9-triazaspiro[5.5]undecane-2,5-dione hydrochloride::9-(1,4-benzodioxane-6-yl)-1-butyl-3-cyclohexyl-1,4,9-triazaspiro-[5.5]undeca-2,5-dione hydrochloride::CHEMBL556798

SMILES CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C11CCN(Cc2ccc3OCCOc3c2)CC1

InChI Key InChIKey=VBONNDPACFTZMX-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50190513   

TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50190513((RS)-1-butyl-3-(cyclohexylmethyl)-9-((2,3-dihydrob...)
Affinity DataIC50:  50nMAssay Description:Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP1alpha-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50190513((RS)-1-butyl-3-(cyclohexylmethyl)-9-((2,3-dihydrob...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of radio-isotope labeled SDF1-alpha binding to human recombinant CXCR4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50190513((RS)-1-butyl-3-(cyclohexylmethyl)-9-((2,3-dihydrob...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity against human recombinant CCR2 expressed in CHO cells assessed as inhibition of human MCP1-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50190513((RS)-1-butyl-3-(cyclohexylmethyl)-9-((2,3-dihydrob...)
Affinity DataIC50:  20nMAssay Description:Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50190513((RS)-1-butyl-3-(cyclohexylmethyl)-9-((2,3-dihydrob...)
Affinity DataIC50:  2.07E+3nMAssay Description:Binding affinity to muscarinic M3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50190513((RS)-1-butyl-3-(cyclohexylmethyl)-9-((2,3-dihydrob...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of radio-isotope labeled MIP1-alpha binding to human recombinant CCR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50190513((RS)-1-butyl-3-(cyclohexylmethyl)-9-((2,3-dihydrob...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity against human recombinant CXCR4 expressed in CHO cells assessed as inhibition of human SDF1-alpha-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50190513((RS)-1-butyl-3-(cyclohexylmethyl)-9-((2,3-dihydrob...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of radio-isotope labeled MCP1 binding to human recombinant CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50190513((RS)-1-butyl-3-(cyclohexylmethyl)-9-((2,3-dihydrob...)
Affinity DataIC50:  183nMAssay Description:Binding affinity to sigma receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed