BDBM50191468 CHEMBL3984494

SMILES Nc1n[nH]c2ccc(cc12)C(=O)N1CCCC[C@H]1c1ccc(F)cc1

InChI Key InChIKey=VXYMGUGNDZARSZ-KRWDZBQOSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50191468   

TargetCyclin-C(Homo sapiens (Human))
Merck

Curated by ChEMBL

LigandBDBM50191468(CHEMBL3984494)Copy SMILESCopy InChI

Affinity DataIC50:  45nMAssay Description:Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Merck

Curated by ChEMBL

LigandBDBM50191468(CHEMBL3984494)Copy SMILESCopy InChI

Affinity DataIC50:  800nMAssay Description:Inhibition of CDK8 in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI