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BDBM50191948 4-cyano-5-ethyl-3-(2'-fluoro-biphenyl-4-yl)-1-methyl-1H-pyrrole-2-carboxylic acid::CHEMBL215575

SMILES: CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1F

InChI Key: InChIKey=ONOQSBGHIPAOLO-UHFFFAOYSA-N

Data: 4 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50191948   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50191948
PNG
(4-cyano-5-ethyl-3-(2'-fluoro-biphenyl-4-yl)-1-meth...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1F
Show InChI InChI=1S/C21H17FN2O2/c1-3-18-16(12-23)19(20(21(25)26)24(18)2)14-10-8-13(9-11-14)15-6-4-5-7-17(15)22/h4-11H,3H2,1-2H3,(H,25,26)
PDB
MMDB

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KEGG

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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 185n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens)
BDBM50191948
PNG
(4-cyano-5-ethyl-3-(2'-fluoro-biphenyl-4-yl)-1-meth...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1F
Show InChI InChI=1S/C21H17FN2O2/c1-3-18-16(12-23)19(20(21(25)26)24(18)2)14-10-8-13(9-11-14)15-6-4-5-7-17(15)22/h4-11H,3H2,1-2H3,(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 80n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
GRIA2


(HUMAN)
BDBM50191948
PNG
(4-cyano-5-ethyl-3-(2'-fluoro-biphenyl-4-yl)-1-meth...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1F
Show InChI InChI=1S/C21H17FN2O2/c1-3-18-16(12-23)19(20(21(25)26)24(18)2)14-10-8-13(9-11-14)15-6-4-5-7-17(15)22/h4-11H,3H2,1-2H3,(H,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 111n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
GRIA2


(HUMAN)
BDBM50191948
PNG
(4-cyano-5-ethyl-3-(2'-fluoro-biphenyl-4-yl)-1-meth...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1F
Show InChI InChI=1S/C21H17FN2O2/c1-3-18-16(12-23)19(20(21(25)26)24(18)2)14-10-8-13(9-11-14)15-6-4-5-7-17(15)22/h4-11H,3H2,1-2H3,(H,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 143n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR2 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair