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BDBM50192833 CHEMBL3923083::US10188627, Compound 8j

SMILES: CC(CCCOc1ccccc1CN(C)C(=O)c1ccc(cc1)-c1ccco1)CC(O)=O

InChI Key: InChIKey=NOHPKKZHDRVOAF-UHFFFAOYNA-N

Data: 4 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50192833   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50192833
PNG
(CHEMBL3923083 | US10188627, Compound 8j)
Show SMILES CC(CCCOc1ccccc1CN(C)C(=O)c1ccc(cc1)-c1ccco1)CC(O)=O
Show InChI InChI=1/C26H29NO5/c1-19(17-25(28)29)7-5-15-32-24-9-4-3-8-22(24)18-27(2)26(30)21-13-11-20(12-14-21)23-10-6-16-31-23/h3-4,6,8-14,16,19H,5,7,15,17-18H2,1-2H3,(H,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 566n/an/an/an/a



Temple University

Curated by ChEMBL


Assay Description
Transactivation of human Gal4-PPARdelta LBD transfected in African green monkey CV1 cells after 24 hrs by luciferase reporter gene assay


ACS Med Chem Lett 7: 824-5 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00301
BindingDB Entry DOI: 10.7270/Q2WH2RZ8
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50192833
PNG
(CHEMBL3923083 | US10188627, Compound 8j)
Show SMILES CC(CCCOc1ccccc1CN(C)C(=O)c1ccc(cc1)-c1ccco1)CC(O)=O
Show InChI InChI=1/C26H29NO5/c1-19(17-25(28)29)7-5-15-32-24-9-4-3-8-22(24)18-27(2)26(30)21-13-11-20(12-14-21)23-10-6-16-31-23/h3-4,6,8-14,16,19H,5,7,15,17-18H2,1-2H3,(H,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
US Patent
n/an/an/an/a 566n/an/an/an/a



Mitobridge, Inc.

US Patent


Assay Description
Cell Handling: PathHunter NHR cell lines were expanded from freezer stocks according to standard procedures. Cells were seeded in a total volume of 2...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2HX1FR6
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50192833
PNG
(CHEMBL3923083 | US10188627, Compound 8j)
Show SMILES CC(CCCOc1ccccc1CN(C)C(=O)c1ccc(cc1)-c1ccco1)CC(O)=O
Show InChI InChI=1/C26H29NO5/c1-19(17-25(28)29)7-5-15-32-24-9-4-3-8-22(24)18-27(2)26(30)21-13-11-20(12-14-21)23-10-6-16-31-23/h3-4,6,8-14,16,19H,5,7,15,17-18H2,1-2H3,(H,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
US Patent
n/an/an/an/a 64.5n/an/an/an/a



Mitobridge, Inc.

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2HX1FR6
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50192833
PNG
(CHEMBL3923083 | US10188627, Compound 8j)
Show SMILES CC(CCCOc1ccccc1CN(C)C(=O)c1ccc(cc1)-c1ccco1)CC(O)=O
Show InChI InChI=1/C26H29NO5/c1-19(17-25(28)29)7-5-15-32-24-9-4-3-8-22(24)18-27(2)26(30)21-13-11-20(12-14-21)23-10-6-16-31-23/h3-4,6,8-14,16,19H,5,7,15,17-18H2,1-2H3,(H,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 65n/an/an/an/a



Temple University

Curated by ChEMBL


Assay Description
Transactivation of ProLink tagged human PPARdelta transfected in CHO-K1 cells assessed as interaction with EA labelled SRCP after 3 to 16 hrs by beta...


ACS Med Chem Lett 7: 824-5 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00301
BindingDB Entry DOI: 10.7270/Q2WH2RZ8
More data for this
Ligand-Target Pair