BDBM50193584 3-benzyl-1-methyl-9-phenylpyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-one::CHEMBL213425

SMILES Cc1nn(Cc2ccccc2)c(=O)c2ncn3nc(cc3c12)-c1ccccc1

InChI Key InChIKey=SGZFBLCNGYGISG-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50193584   

TargetAdenosine receptor A1(Homo sapiens (Human))
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50193584(3-benzyl-1-methyl-9-phenylpyrazolo[1',5':1,6]pyrim...)
Affinity DataKi:  104nMAssay Description:Binding affinity to human adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50193584(3-benzyl-1-methyl-9-phenylpyrazolo[1',5':1,6]pyrim...)
Affinity DataKi:  7.56E+3nMAssay Description:Displacement of [3H]DPCPX from human adenosine A2b receptor expressed in HEK293 cells after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50193584(3-benzyl-1-methyl-9-phenylpyrazolo[1',5':1,6]pyrim...)
Affinity DataIC50:  180nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50193584(3-benzyl-1-methyl-9-phenylpyrazolo[1',5':1,6]pyrim...)
Affinity DataIC50:  860nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50193584(3-benzyl-1-methyl-9-phenylpyrazolo[1',5':1,6]pyrim...)
Affinity DataIC50:  180nMAssay Description:Inhibition of human platelets PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed