BDBM50193995 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile::CHEMBL221959::CP-690550::TOFACITINIB CITRATE::Tofacitinib::Tofacitinib citrate (1)::US10112907, Example 00035::US10399979, Compound Tofacitinib::US10766894, Compound TABLE 1.20::US10875847, Compound Tofacitinib::US11078206, Example Tofacitinib::US11203595, TABLE 1.20::US11339167, Example Tofacitinib::US20240140952, Compound Tofacitinib

SMILES: C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N

InChI Key: InChIKey=UJLAWZDWDVHWOW-UHFFFAOYSA-N

Data: 25 KI  334 IC50  783 Kd  11 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1204 hits for monomerid = 50193995   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 [866-1154] (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	7.5	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	30	n/a	n/a	n/a	n/a	7.5	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 [811-1124] (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	7.5	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [888-1187] (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	230	n/a	n/a	n/a	n/a	7.5	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 3 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	640	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase DCLK3 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
NUAK family SNF1-like kinase 2 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	420	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.76E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 [781-1124] (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.496	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.292	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.60	n/a	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	15	n/a	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.10	n/a	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	72	n/a	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.960	n/a	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	45	n/a	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	41	n/a	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	472	n/a	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.42	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.09	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.241	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10.4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.35	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154] (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 [811-1124] (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [888-1187] (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	302	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50193995 (CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	77	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair