BDBM50194024 3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-phenoxyphenylamino)isothiazole-4-carboximidamide::CHEMBL437331

SMILES CC(CO)N=C(N)c1c(Nc2ccc(Oc3ccccc3)cc2)s[nH]c1=O

InChI Key InChIKey=QDWSVWMOWVHELW-UHFFFAOYSA-N

Data  7 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50194024   

TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194024(3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-phenoxypheny...)
Affinity DataIC50:  33nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194024(3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-phenoxypheny...)
Affinity DataEC50:  42nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194024(3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-phenoxypheny...)
Affinity DataIC50:  26nMAssay Description:Inhibition of MEK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194024(3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-phenoxypheny...)
Affinity DataIC50:  455nMAssay Description:Inhibition of AxlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194024(3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-phenoxypheny...)
Affinity DataIC50:  142nMAssay Description:Inhibition of CHK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1/beta-2(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194024(3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-phenoxypheny...)
Affinity DataIC50:  2.62E+3nMAssay Description:Inhibition of p70 S6 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194024(3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-phenoxypheny...)
Affinity DataIC50:  260nMAssay Description:Inhibition of AuroraMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194024(3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-phenoxypheny...)
Affinity DataIC50:  795nMAssay Description:Inhibition of Flt-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed