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BDBM50194582 CHEMBL375538::N'-(5-fluoro-3-methoxy-2-phenyl-quinoline-4-carbonyl)-N-phenyl-hydrazinecarboxylic acid methyl ester

SMILES: COC(=O)N(NC(=O)c1c(OC)c(nc2cccc(F)c12)-c1ccccc1)c1ccccc1

InChI Key: InChIKey=DMNUFQWKNGJXEJ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50194582   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50194582
PNG
(CHEMBL375538 | N'-(5-fluoro-3-methoxy-2-phenyl-qui...)
Show SMILES COC(=O)N(NC(=O)c1c(OC)c(nc2cccc(F)c12)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H20FN3O4/c1-32-23-21(24(30)28-29(25(31)33-2)17-12-7-4-8-13-17)20-18(26)14-9-15-19(20)27-22(23)16-10-5-3-6-11-16/h3-15H,1-2H3,(H,28,30)
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PC sid
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Similars

Article
PubMed
n/an/a 11n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cells


Bioorg Med Chem Lett 16: 5748-51 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.086
BindingDB Entry DOI: 10.7270/Q2W66MK3
More data for this
Ligand-Target Pair