BDBM50194673 4-methyl-N-(2-methyl-3-(trifluoromethyl)phenyl)-3-(2-(2-(pyrrolidin-1-yl)ethylamino)quinazolin-6-yl)benzamide::CHEMBL214556

SMILES Cc1ccc(cc1-c1ccc2nc(NCCN3CCCC3)ncc2c1)C(=O)Nc1cccc(c1C)C(F)(F)F

InChI Key InChIKey=RKNYQDPVAHZMFZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50194673   

TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194673(4-methyl-N-(2-methyl-3-(trifluoromethyl)phenyl)-3-...)
Affinity DataIC50:  6nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194673(4-methyl-N-(2-methyl-3-(trifluoromethyl)phenyl)-3-...)
Affinity DataIC50:  7nMAssay Description:Inhibition of p38-alpha by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194673(4-methyl-N-(2-methyl-3-(trifluoromethyl)phenyl)-3-...)
Affinity DataIC50:  246nMAssay Description:Inhibition of KDR by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194673(4-methyl-N-(2-methyl-3-(trifluoromethyl)phenyl)-3-...)
Affinity DataIC50: >8.33E+3nMAssay Description:Inhibition of Jak3 by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed