BDBM50195876 3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phenyl)-ureido]-phenyl}-furo[3,2-c]pyridin-7-yl)-benzenesulfonamide::CHEMBL241682

SMILES Nc1ncc(-c2cccc(c2)S(N)(=O)=O)c2occ(-c3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)c12

InChI Key InChIKey=CASSAPBDIVDPCC-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50195876   

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50195876(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IKK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50195876(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ErbB2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50195876(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50195876(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50195876(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of human recombinant GST-6XHis-VEGFR2 by HTRF methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50195876(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50195876(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of GSK3bMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50195876(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Akt3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50195876(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MAPKAPK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50195876(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human recombinant GST-Tie2 by HTRF methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed