BDBM14027 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline::5-(1,4-diazepane-1-sulfonyl)isoquinoline::AT877::CHEMBL38380::CHEMBL541388::Fasudil (HA-1077)::HA-1077::US20240246972, Compound Fasudil::US9687483, Fasudil::cid_163751

SMILES: c1cc2cnccc2c(c1)S(=O)(=O)N3CCCNCC3

InChI Key: InChIKey=NGOGFTYYXHNFQH-UHFFFAOYSA-N

Data: 11 KI  66 IC50  3 Kd  1 EC50

PDB links: 15 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 79 hits for monomerid = 14027   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 1 (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	660	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Myosin light chain kinase, smooth muscle (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.16E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-5 (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase N2 (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Rat)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase N2 (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	780	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cell division control protein 42 homolog (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein kinase C epsilon type (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase N1 (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Myotonin-protein kinase (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1/2 (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
C-C chemokine receptor type 2 (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	158	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Rat)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	820	n/a	n/a	n/a	n/a	n/a	23
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.23E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein kinase C epsilon type (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	158	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
C-C motif chemokine 2 (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.92E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.35E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.16E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.17E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase N2 (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	780	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.58E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cell division control protein 42 homolog (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	660	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Myosin light chain kinase, smooth muscle (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
MO15-related protein kinase Pfmrk (malaria parasite P. falciparum)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1/2 (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
C-C chemokine receptor type 2 (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha [V123M,T183A] (Bovine)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.35E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.58E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	71	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	853	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Bovine)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	485	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha [L49I,V123M,E127D,Q181K,T183A] (Bovine)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.28E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha [L49I,V123M,Q181K,T183A] (Bovine)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.13E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha [V123M,Q181K,T183A] (Bovine)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.95E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha [L49I,Q181K,T183A] (Bovine)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	870	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 33 (Human)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	9.58E+3	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha [Q181K,T183A] (Bovine)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	541	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha [E127D] (Bovine)	BDBM14027 (AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.45E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair