BDBM50197412 CHEMBL241711::N-(5-carbamoylmethanesulfonyl-adamantan-2-yl)-2-(2-chloro-4-fluoro-phenoxy)-2-methyl-propionamide

SMILES CC(C)(Oc1ccc(F)cc1Cl)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(=O)(=O)CC(N)=O

InChI Key InChIKey=PEERJNNYPXHLDJ-JPWRKOPWSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50197412   

Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50197412(CHEMBL241711 | N-(5-carbamoylmethanesulfonyl-adama...)
Affinity DataKi:  4nMAssay Description:Inhibition of mouse HSD1 assessed as interconversion of cortisone to cortisolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50197412(CHEMBL241711 | N-(5-carbamoylmethanesulfonyl-adama...)
Affinity DataKi:  8nMAssay Description:Inhibition of human HSD1 assessed as interconversion of cortisone to cortisolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50197412(CHEMBL241711 | N-(5-carbamoylmethanesulfonyl-adama...)
Affinity DataIC50:  300nMAssay Description:Inhibition of human HSD1 expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50197412(CHEMBL241711 | N-(5-carbamoylmethanesulfonyl-adama...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mouse HSD2 assessed as interconversion of cortisone to cortisolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50197412(CHEMBL241711 | N-(5-carbamoylmethanesulfonyl-adama...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of human HSD2 assessed as interconversion of cortisone to cortisolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed