BDBM50197954 CHEBI:2965::CHEMBL314691

SMILES CC(C)C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C

InChI Key InChIKey=VYCMAAOURFJIHD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50197954   

TargetEndothelin-1 receptor(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50197954(CHEBI:2965 | CHEMBL314691)
Affinity DataIC50: 0.620nMAssay Description:Antagonist activity at ETA receptor in human SKNMC cells assessed as inhibition of endothelin-1-mediated Ca2+ mobilization by fura-2/AM dye-based spe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Rat)TBA
LigandPNGBDBM50197954(CHEBI:2965 | CHEMBL314691)
Affinity DataIC50: 28nMAssay Description:Displacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetEndothelin-1 receptor(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50197954(CHEBI:2965 | CHEMBL314691)
Affinity DataIC50: 37nMAssay Description:Antagonist activity at Homo sapiens (human) ETA receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article