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BDBM50198425 1-(2,4-dichlorobenzyl)-N-(5-(diethylamino)pentan-2-yl)-1H-pyrazolo[3,4-b]pyridin-6-amine::CHEMBL396787

SMILES: CCN(CC)CCCC(C)Nc1ccc2cnn(Cc3ccc(Cl)cc3Cl)c2n1

InChI Key: InChIKey=WVFBWTWTRQHWIC-UHFFFAOYNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50198425   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
C-C chemokine receptor type 4 (CCR4)


(Homo sapiens (Human))
BDBM50198425
PNG
(1-(2,4-dichlorobenzyl)-N-(5-(diethylamino)pentan-2...)
Show SMILES CCN(CC)CCCC(C)Nc1ccc2cnn(Cc3ccc(Cl)cc3Cl)c2n1
Show InChI InChI=1/C22H29Cl2N5/c1-4-28(5-2)12-6-7-16(3)26-21-11-9-17-14-25-29(22(17)27-21)15-18-8-10-19(23)13-20(18)24/h8-11,13-14,16H,4-7,12,15H2,1-3H3,(H,26,27)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 280n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]MDC from human CCR4 expressed in HEK293 cells


Bioorg Med Chem Lett 17: 679-82 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.091
BindingDB Entry DOI: 10.7270/Q24B310V
More data for this
Ligand-Target Pair