BindingDB logo
myBDB logout

BDBM50199669 3-cyclobutyl-1-(3-(cyclopropylmethoxy)phenyl)imidazo[1,5-a]pyrazin-8-amine::CHEMBL391746

SMILES: Nc1nccn2c(nc(-c3cccc(OCC4CC4)c3)c12)C1CCC1

InChI Key: InChIKey=KURHPQXMOMJQAI-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50199669   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50199669
PNG
(3-cyclobutyl-1-(3-(cyclopropylmethoxy)phenyl)imida...)
Show SMILES Nc1nccn2c(nc(-c3cccc(OCC4CC4)c3)c12)C1CCC1
Show InChI InChI=1S/C20H22N4O/c21-19-18-17(15-5-2-6-16(11-15)25-12-13-7-8-13)23-20(14-3-1-4-14)24(18)10-9-22-19/h2,5-6,9-11,13-14H,1,3-4,7-8,12H2,(H2,21,22)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.27E+3n/an/an/an/an/an/a



OSI Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-IGF1R activity


Bioorg Med Chem Lett 17: 1091-7 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB
More data for this
Ligand-Target Pair