BindingDB logo
myBDB logout

BDBM50199673 3-cyclobutyl-1-(3-(cyclopentyloxy)phenyl)imidazo[1,5-a]pyrazin-8-amine::CHEMBL245612

SMILES: Nc1nccn2c(nc(-c3cccc(OC4CCCC4)c3)c12)C1CCC1

InChI Key: InChIKey=WWJGJSUCEUBRKD-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50199673   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50199673
PNG
(3-cyclobutyl-1-(3-(cyclopentyloxy)phenyl)imidazo[1...)
Show SMILES Nc1nccn2c(nc(-c3cccc(OC4CCCC4)c3)c12)C1CCC1
Show InChI InChI=1S/C21H24N4O/c22-20-19-18(24-21(14-5-3-6-14)25(19)12-11-23-20)15-7-4-10-17(13-15)26-16-8-1-2-9-16/h4,7,10-14,16H,1-3,5-6,8-9H2,(H2,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.50E+3n/an/an/an/an/an/a



OSI Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-IGF1R activity


Bioorg Med Chem Lett 17: 1091-7 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB
More data for this
Ligand-Target Pair