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BDBM50200783 ADS-103168::CHEMBL424739::N-(2-(pyrrolidin-1-yl)-1H-benzo[d]imidazol-6-yl)-2-(4-(trifluoromethyl)phenoxy)acetamide

SMILES: FC(F)(F)c1ccc(OCC(=O)Nc2ccc3nc([nH]c3c2)N2CCCC2)cc1

InChI Key: InChIKey=UWZAIHJEZDRIJB-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50200783   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50200783
PNG
(ADS-103168 | CHEMBL424739 | N-(2-(pyrrolidin-1-yl)...)
Show SMILES FC(F)(F)c1ccc(OCC(=O)Nc2ccc3nc([nH]c3c2)N2CCCC2)cc1
Show InChI InChI=1S/C20H19F3N4O2/c21-20(22,23)13-3-6-15(7-4-13)29-12-18(28)24-14-5-8-16-17(11-14)26-19(25-16)27-9-1-2-10-27/h3-8,11H,1-2,9-10,12H2,(H,24,28)(H,25,26)
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UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 35n/an/an/an/an/an/a



Argenta Discovery Limited

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from MCH-R1 expressing cell membranes


Bioorg Med Chem Lett 17: 1403-7 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.092
BindingDB Entry DOI: 10.7270/Q2G73DCD
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50200783
PNG
(ADS-103168 | CHEMBL424739 | N-(2-(pyrrolidin-1-yl)...)
Show SMILES FC(F)(F)c1ccc(OCC(=O)Nc2ccc3nc([nH]c3c2)N2CCCC2)cc1
Show InChI InChI=1S/C20H19F3N4O2/c21-20(22,23)13-3-6-15(7-4-13)29-12-18(28)24-14-5-8-16-17(11-14)26-19(25-16)27-9-1-2-10-27/h3-8,11H,1-2,9-10,12H2,(H,24,28)(H,25,26)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 9n/an/an/an/an/an/a



Argenta Discovery Limited

Curated by ChEMBL


Assay Description
Inhibition of MCH-mediated calcium influx into MCH-R1 expressing cells


Bioorg Med Chem Lett 17: 1403-7 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.092
BindingDB Entry DOI: 10.7270/Q2G73DCD
More data for this
Ligand-Target Pair