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BDBM50201146 3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)-4-(2-(3-chloro-4-propoxyphenyl)-2-hydroxyethylamino)pyridin-2(1H)-one::CHEMBL425995

SMILES: CCCOc1ccc(cc1Cl)C(O)CNc1cc[nH]c(=O)c1-c1nc2cc(cc(C)c2[nH]1)-n1ccnc1

InChI Key: InChIKey=QCLLJBIDXQRZLO-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50201146   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50201146
PNG
(3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidaz...)
Show SMILES CCCOc1ccc(cc1Cl)C(O)CNc1cc[nH]c(=O)c1-c1nc2cc(cc(C)c2[nH]1)-n1ccnc1
Show InChI InChI=1S/C27H27ClN6O3/c1-3-10-37-23-5-4-17(12-19(23)28)22(35)14-31-20-6-7-30-27(36)24(20)26-32-21-13-18(34-9-8-29-15-34)11-16(2)25(21)33-26/h4-9,11-13,15,22,35H,3,10,14H2,1-2H3,(H,32,33)(H2,30,31,36)
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Article
PubMed
n/an/a>2.50E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of IGF1R


Bioorg Med Chem Lett 17: 974-7 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.041
BindingDB Entry DOI: 10.7270/Q25T3K4D
More data for this
Ligand-Target Pair