BDBM50201564 CHEMBL3890777

SMILES NC(=O)c1nn(CC(=O)N2CCS[C@H]2C(=O)Nc2cccc(Br)n2)c2ncccc12

InChI Key InChIKey=AOOWOKALXAVACG-SFHVURJKSA-N

Data  3 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50201564   

TargetComplement factor D(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50201564(CHEMBL3890777)
Affinity DataIC50:  19nMAssay Description:Inhibition of recombinant human C-terminal 6His-tagged complement factor D (26 to 253 residues) expressed in Sf9 insect cells preincubated for 1 hr f...More data for this Ligand-Target Pair
TargetComplement factor D(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50201564(CHEMBL3890777)
Affinity DataIC50:  205nMAssay Description:Inhibition of human serum factor D-mediated complement activation in rabbit erythrocytes assessed as reduction in rabbit erythrocyte hemolysis preinc...More data for this Ligand-Target Pair
TargetComplement factor D(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50201564(CHEMBL3890777)
Affinity DataIC50:  27nMAssay Description:Competitive inhibition of human complement factor D preincubated for 1 hr followed by addition of Z-Lys-thiobenzyl ester as substrate measured over 5...More data for this Ligand-Target Pair
TargetComplement factor D(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50201564(CHEMBL3890777)
Affinity DataKd:  19nMAssay Description:Binding affinity to recombinant human C-terminal 6His-tagged/biotinylated complement factor D (26 to 253 residues) expressed in Sf9 insect cells by b...More data for this Ligand-Target Pair