BDBM50201811 CHEMBL3966342

SMILES Cc1cnc(Nc2ccc(cc2)N2CCOCC2)nc1-c1cc2cc(ccc2o1)C#N

InChI Key InChIKey=VKRJEIZKZXYZBP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50201811   

TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50201811(CHEMBL3966342)
Affinity DataIC50:  364nMAssay Description:Inhibition of GST-tagged recombinant human cytoplasmic JAK3 expressed in baculovirus using TK-substrate-biotin as substrate preincubated for 5 mins f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Mus musculus)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50201811(CHEMBL3966342)
Affinity DataIC50:  1.72E+3nMAssay Description:Inhibition of JAK3 in mouse HT2 cells assessed as suppression of cell growthMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50201811(CHEMBL3966342)
Affinity DataIC50:  10nMAssay Description:Inhibition of GST-tagged recombinant human JAK2 expressed in baculovirus using TK-substrate-biotin as substrate preincubated for 5 mins followed by s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50201811(CHEMBL3966342)
Affinity DataIC50:  1.05E+3nMAssay Description:Inhibition of JAK2 in human TF1 cells assessed as suppression of cell growthMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed