BDBM50203710 CHEMBL3891534

SMILES [H][C@@]12CCO[C@@]1(N=C(N)SC2)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F

InChI Key InChIKey=IRMOIEQGSGUCMN-XTZNXHDOSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50203710   

TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50203710(CHEMBL3891534)
Affinity DataIC50:  24nMAssay Description:Inhibition of BACE1 in human H4 cells transfected with APP751 assessed as reduction in amyloidbeta level incubated for 19 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50203710(CHEMBL3891534)
Affinity DataIC50:  20nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed