BDBM50204294 CHEMBL3943295::US20230295171, Example 8

SMILES Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)nc3CNC(=O)c23)c1

InChI Key InChIKey=VPNLOOYVNORYBV-UONOGXRCSA-N

Data  3 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50204294   

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50204294(CHEMBL3943295 | US20230295171, Example 8)
Affinity DataEC50:  35nMAssay Description:Inhibition of SYK in TgM-stimulated human Ramos cells expressing RA1/GFP-tagged BLNK assessed as reduction in RA1/GFP-tagged BLNK phosphorylation pre...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50204294(CHEMBL3943295 | US20230295171, Example 8)
Affinity DataIC50:  7.94nMAssay Description:YK protein is prepared from cDNA encoding human spleen tyrosine kinase and is expressed in insect cells using a baculovirus expression vector. The cD...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50204294(CHEMBL3943295 | US20230295171, Example 8)
Affinity DataIC50:  7.94nMAssay Description:YK protein is prepared from cDNA encoding human spleen tyrosine kinase and is expressed in insect cells using a baculovirus expression vector. The cD...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50204294(CHEMBL3943295 | US20230295171, Example 8)
Affinity DataIC50:  13nMAssay Description:Inhibition of human C-terminal 6His-tagged SYK (356 to 635 residues) expressed in Sf9 insect cells using 5-carboxyfluorescein(FAM)-EEPLYWSFPAKKK-NH2 ...More data for this Ligand-Target Pair