BDBM50204695 4'-[6-(4-Hydroxy-cyclohexylmethyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl]-biphenyl-4-ol::CHEMBL242325

SMILES OC1CCN(Cc2ccc-3c(Cc4c(n[nH]c-34)-c3ccc(cc3)-c3ccc(O)cc3)c2)CC1

InChI Key InChIKey=CTVYVVBTBHTZBT-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50204695   

TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50204695(4'-[6-(4-Hydroxy-cyclohexylmethyl)-1,4-dihydroinde...)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant CHK1 assessed as human Cdc25C phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50204695(4'-[6-(4-Hydroxy-cyclohexylmethyl)-1,4-dihydroinde...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of G2/M cell population in human H1299 cells by FACS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50204695(4'-[6-(4-Hydroxy-cyclohexylmethyl)-1,4-dihydroinde...)
Affinity DataEC50:  4.70E+3nMAssay Description:Inhibition of cell proliferation in human HeLa cells by MTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed