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BDBM50205280 2,6-diphenyl-8-isobutyl-1-deazapurine::CHEMBL221486::LUF-5978

SMILES: CC(C)Cc1nc2c(cc(nc2[nH]1)-c1ccccc1)-c1ccccc1

InChI Key: InChIKey=PPFWSQNEFCXMGP-UHFFFAOYSA-N

Data: 4 KI

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50205280   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Adenosine receptor A1


(Homo sapiens (human))
BDBM50205280
PNG
(2,6-diphenyl-8-isobutyl-1-deazapurine | CHEMBL2214...)
Show SMILES CC(C)Cc1nc2c(cc(nc2[nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C22H21N3/c1-15(2)13-20-24-21-18(16-9-5-3-6-10-16)14-19(23-22(21)25-20)17-11-7-4-8-12-17/h3-12,14-15H,13H2,1-2H3,(H,23,24,25)
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PubMed
0.550n/an/an/an/an/an/an/an/a



Leiden/Amsterdam Center for Drug Research

Curated by ChEMBL


Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells


J Med Chem 50: 828-34 (2007)


Article DOI: 10.1021/jm0607956
BindingDB Entry DOI: 10.7270/Q2VX0G65
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50205280
PNG
(2,6-diphenyl-8-isobutyl-1-deazapurine | CHEMBL2214...)
Show SMILES CC(C)Cc1nc2c(cc(nc2[nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C22H21N3/c1-15(2)13-20-24-21-18(16-9-5-3-6-10-16)14-19(23-22(21)25-20)17-11-7-4-8-12-17/h3-12,14-15H,13H2,1-2H3,(H,23,24,25)
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25n/an/an/an/an/an/an/an/a



Leiden/Amsterdam Center for Drug Research

Curated by ChEMBL


Assay Description
Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells


J Med Chem 50: 828-34 (2007)


Article DOI: 10.1021/jm0607956
BindingDB Entry DOI: 10.7270/Q2VX0G65
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (human))
BDBM50205280
PNG
(2,6-diphenyl-8-isobutyl-1-deazapurine | CHEMBL2214...)
Show SMILES CC(C)Cc1nc2c(cc(nc2[nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C22H21N3/c1-15(2)13-20-24-21-18(16-9-5-3-6-10-16)14-19(23-22(21)25-20)17-11-7-4-8-12-17/h3-12,14-15H,13H2,1-2H3,(H,23,24,25)
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189n/an/an/an/an/an/an/an/a



Leiden/Amsterdam Center for Drug Research

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in CHO cells


J Med Chem 50: 828-34 (2007)


Article DOI: 10.1021/jm0607956
BindingDB Entry DOI: 10.7270/Q2VX0G65
More data for this
Ligand-Target Pair
Adenosine receptor A2b


(Homo sapiens (Human))
BDBM50205280
PNG
(2,6-diphenyl-8-isobutyl-1-deazapurine | CHEMBL2214...)
Show SMILES CC(C)Cc1nc2c(cc(nc2[nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C22H21N3/c1-15(2)13-20-24-21-18(16-9-5-3-6-10-16)14-19(23-22(21)25-20)17-11-7-4-8-12-17/h3-12,14-15H,13H2,1-2H3,(H,23,24,25)
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300n/an/an/an/an/an/an/an/a



Leiden/Amsterdam Center for Drug Research

Curated by ChEMBL


Assay Description
Displacement of [3H]MRS1754 from human adenosine A2B receptor


J Med Chem 50: 828-34 (2007)


Article DOI: 10.1021/jm0607956
BindingDB Entry DOI: 10.7270/Q2VX0G65
More data for this
Ligand-Target Pair