BDBM50205415 ({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid::CHEMBL220940

SMILES Cc1cn([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)[nH]c1=O

InChI Key InChIKey=RZCIEJXAILMSQK-JXOAFFINSA-N

Data  2 KI  5 IC50  2 Kd  3 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50205415   

TargetThymidine kinase, cytosolic(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50205415(({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methyl-2,4-...)
Affinity DataKi:  3.70E+3nMAssay Description:Evaluated for the mixed objective Non-competitive inhibition constant Ki against TdR varied rat mitochondrial thymidine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine kinase, cytosolic(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50205415(({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methyl-2,4-...)
Affinity DataKi:  6.50E+3nMAssay Description:Evaluated for the Non-competitive inhibition constant Ki against TdR varied rat cytoplasmic soluble thymidine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Max-Delbr�Ck-Centrum F�R Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50205415(({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methyl-2,4-...)
Affinity DataIC50: >2.00E+5nMAssay Description:Compound was evaluated for 50% inhibition of HIV-RT (HIV reverse transcriptase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Max-Delbr�Ck-Centrum F�R Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50205415(({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methyl-2,4-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Compound was evaluated for 50% inhibition of DHBV DNA polymerase (duck hepatitis B virus)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Veterans Affairs Medical Center

Curated by ChEMBL
LigandPNGBDBM50205415(({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methyl-2,4-...)
Affinity DataKd:  2.10E+3nMAssay Description:Binding affinity to HIV1 reverse transcriptase assessed as L-3'-azido-NTP incorporation in nascent DNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 2(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50205415(({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methyl-2,4-...)
Affinity DataEC50:  480nMAssay Description:Agonist activity at human recombinant P2Y2 receptor expressed in 1321N1 cells assessed as stimulation of phospholipase CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 6(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50205415(({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methyl-2,4-...)
Affinity DataEC50:  140nMAssay Description:Agonist activity at human recombinant P2Y6 receptor expressed in 1321N1 cells assessed as stimulation of phospholipase CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 4(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50205415(({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methyl-2,4-...)
Affinity DataEC50:  3.90E+3nMAssay Description:Agonist activity at human recombinant P2Y4 receptor expressed in 1321N1 cells assessed as stimulation of phospholipase CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase protein(Human immunodeficiency virus 1)
Veterans Affairs Medical Center

Curated by ChEMBL
LigandPNGBDBM50205415(({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methyl-2,4-...)
Affinity DataKd:  2.90E+3nMAssay Description:Binding affinity to HIV1 reverse transcriptase M184V mutant assessed as L-3'-azido-NTP incorporation in nascent DNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Max-Delbr�Ck-Centrum F�R Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50205415(({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methyl-2,4-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Compound was evaluated for 50% inhibition of DHBV DNA polymerase (duck hepatitis B virus)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase subunit gamma-1(Homo sapiens (Human))
Max-Delbr�Ck-Centrum F�R Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50205415(({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methyl-2,4-...)
Affinity DataIC50:  8.00E+4nMAssay Description:Compound was evaluated for the inhibition of cellular DNA polymerase (gamma)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Max-Delbr�Ck-Centrum F�R Molekulare Medizin

Curated by ChEMBL
LigandPNGBDBM50205415(({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methyl-2,4-...)
Affinity DataIC50: >2.00E+5nMAssay Description:Compound was evaluated for the inhibition of cellular DNA polymerase (beta)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed