BDBM50206959 CHEMBL3924257

SMILES Cc1c(F)cncc1-c1nc2ccc(F)cn2c1C1CC1

InChI Key InChIKey=BYZQRWHNJVYODK-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50206959   

TargetAromatase(Homo sapiens (Human))
Merck Usa

Curated by ChEMBL
LigandPNGBDBM50206959(CHEMBL3924257)
Affinity DataIC50:  420nMAssay Description:Inhibition of CYP19 (unknown origin) using MFC as substrate and NADPH as cofactor preincubated for 10 mins with cofactor followed by substrate/enzyme...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Merck Usa

Curated by ChEMBL
LigandPNGBDBM50206959(CHEMBL3924257)
Affinity DataIC50:  930nMAssay Description:Inhibition of human CYP11B1-8C7 expressed in Chinese hamster V79 cells using 11-deoxycortisol as substrate preincubated for 1 hr followed by substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Merck Usa

Curated by ChEMBL
LigandPNGBDBM50206959(CHEMBL3924257)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CYP17 expressed in African green monkey COS7 cells using 17-hydroxypregnenolone as substrate preincubated for 1 hr followed by su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 21-hydroxylase(Homo sapiens (Human))
Merck Usa

Curated by ChEMBL
LigandPNGBDBM50206959(CHEMBL3924257)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CYP21 expressed in African green monkey COS7 cells using 17-hydroxypregnenolone as substrate preincubated for 1 hr followed by su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Merck Usa

Curated by ChEMBL
LigandPNGBDBM50206959(CHEMBL3924257)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of human CYP11B2-CLE9 expressed in Chinese hamster V79 cells using 11-deoxycorticosterone as substrate preincubated for 1 hr followed by s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck Usa

Curated by ChEMBL
LigandPNGBDBM50206959(CHEMBL3924257)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of hepatic CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed