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BDBM50207124 3-(cyclohexylmethyl)-8-((6,7-dimethoxyisoquinolin-4-yl)methyl)-1-methyl-1H-purine-2,6(3H,7H)-dione::CHEMBL247285

SMILES: COc1cc2cncc(Cc3nc4n(CC5CCCCC5)c(=O)n(C)c(=O)c4[nH]3)c2cc1OC

InChI Key: InChIKey=LLGVTHHLBJOXHZ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50207124   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50207124
PNG
(3-(cyclohexylmethyl)-8-((6,7-dimethoxyisoquinolin-...)
Show SMILES COc1cc2cncc(Cc3nc4n(CC5CCCCC5)c(=O)n(C)c(=O)c4[nH]3)c2cc1OC
Show InChI InChI=1S/C25H29N5O4/c1-29-24(31)22-23(30(25(29)32)14-15-7-5-4-6-8-15)28-21(27-22)10-17-13-26-12-16-9-19(33-2)20(34-3)11-18(16)17/h9,11-13,15H,4-8,10,14H2,1-3H3,(H,27,28)
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Article
PubMed
n/an/a 28n/an/an/an/an/an/a



Novartis Institutes of BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assay


Bioorg Med Chem Lett 17: 2376-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.019
BindingDB Entry DOI: 10.7270/Q2X63NSC
More data for this
Ligand-Target Pair