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BDBM50207771 CHEMBL245708::adamantan-1-yl-(4-phenethyl-piperazin-1-yl)-methanone

SMILES: O=C(N1CCN(CCc2ccccc2)CC1)C12CC3CC(CC(C3)C1)C2

InChI Key: InChIKey=VSFYVNDRAWTPAR-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50207771   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50207771
PNG
(CHEMBL245708 | adamantan-1-yl-(4-phenethyl-piperaz...)
Show SMILES O=C(N1CCN(CCc2ccccc2)CC1)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C23H32N2O/c26-22(23-15-19-12-20(16-23)14-21(13-19)17-23)25-10-8-24(9-11-25)7-6-18-4-2-1-3-5-18/h1-5,19-21H,6-17H2
PDB
MMDB

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PC cid
PC sid
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Similars

Article
PubMed
n/an/a 4.70E+4n/an/an/an/an/an/a



University of Edinburgh

Curated by ChEMBL


Assay Description
Inhibition of human 11beta-HSD1 expressed in HEK293 cells after 2 hrs by scintillation proximity assay


Bioorg Med Chem Lett 17: 2838-43 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.057
BindingDB Entry DOI: 10.7270/Q2CJ8D5S
More data for this
Ligand-Target Pair