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BDBM50207853 3-isopropyl-N-(3-(3-(4-(methylamino)-1,3,5-triazin-2-yl)pyridin-2-yloxy)phenyl)benzamide::CHEMBL245948

SMILES: CNc1ncnc(n1)-c1cccnc1Oc1cccc(NC(=O)c2cccc(c2)C(C)C)c1

InChI Key: InChIKey=ROJPTCGXRHNIRD-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50207853   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50207853
PNG
(3-isopropyl-N-(3-(3-(4-(methylamino)-1,3,5-triazin...)
Show SMILES CNc1ncnc(n1)-c1cccnc1Oc1cccc(NC(=O)c2cccc(c2)C(C)C)c1
Show InChI InChI=1S/C25H24N6O2/c1-16(2)17-7-4-8-18(13-17)23(32)30-19-9-5-10-20(14-19)33-24-21(11-6-12-27-24)22-28-15-29-25(26-3)31-22/h4-16H,1-3H3,(H,30,32)(H,26,28,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 456n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of KDR after 90 mins by HTRF assay


Bioorg Med Chem Lett 17: 2886-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.067
BindingDB Entry DOI: 10.7270/Q2445M4C
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM50207853
PNG
(3-isopropyl-N-(3-(3-(4-(methylamino)-1,3,5-triazin...)
Show SMILES CNc1ncnc(n1)-c1cccnc1Oc1cccc(NC(=O)c2cccc(c2)C(C)C)c1
Show InChI InChI=1S/C25H24N6O2/c1-16(2)17-7-4-8-18(13-17)23(32)30-19-9-5-10-20(14-19)33-24-21(11-6-12-27-24)22-28-15-29-25(26-3)31-22/h4-16H,1-3H3,(H,30,32)(H,26,28,29,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 6n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of Tie2 after 90 mins by HTRF assay


Bioorg Med Chem Lett 17: 2886-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.067
BindingDB Entry DOI: 10.7270/Q2445M4C
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM50207853
PNG
(3-isopropyl-N-(3-(3-(4-(methylamino)-1,3,5-triazin...)
Show SMILES CNc1ncnc(n1)-c1cccnc1Oc1cccc(NC(=O)c2cccc(c2)C(C)C)c1
Show InChI InChI=1S/C25H24N6O2/c1-16(2)17-7-4-8-18(13-17)23(32)30-19-9-5-10-20(14-19)33-24-21(11-6-12-27-24)22-28-15-29-25(26-3)31-22/h4-16H,1-3H3,(H,30,32)(H,26,28,29,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 85n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of Tie2 autophosphorylation in EA.hy926 cells after 2.5 hrs


Bioorg Med Chem Lett 17: 2886-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.067
BindingDB Entry DOI: 10.7270/Q2445M4C
More data for this
Ligand-Target Pair