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BDBM50208138 (+)-acifran::(-)-acifran::5-Methyl-4-oxo-5-phenyl-4,5-dihydro-furan-2-carboxylic acid::5-methyl-4-oxo-5-phenyl-4,5-dihydrofuran-2-carboxylic acid::CHEMBL278488::acifran

SMILES: CC1(OC(=CC1=O)C(O)=O)c1ccccc1

InChI Key: InChIKey=DFDGRKNOFOJBAJ-UHFFFAOYSA-N

Data: 3 IC50  7 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50208138   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HM74 nicotinic acid GPCR


(Homo sapiens (Human))
BDBM50208138
PNG
((+)-acifran | (-)-acifran | 5-Methyl-4-oxo-5-pheny...)
Show SMILES CC1(OC(=CC1=O)C(O)=O)c1ccccc1
Show InChI InChI=1S/C12H10O4/c1-12(8-5-3-2-4-6-8)10(13)7-9(16-12)11(14)15/h2-7H,1H3,(H,14,15)
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Article
PubMed
n/an/an/an/a 4.20E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation


J Med Chem 50: 1445-8 (2007)


Article DOI: 10.1021/jm070022x
BindingDB Entry DOI: 10.7270/Q2BK1C1Z
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))
BDBM50208138
PNG
((+)-acifran | (-)-acifran | 5-Methyl-4-oxo-5-pheny...)
Show SMILES CC1(OC(=CC1=O)C(O)=O)c1ccccc1
Show InChI InChI=1S/C12H10O4/c1-12(8-5-3-2-4-6-8)10(13)7-9(16-12)11(14)15/h2-7H,1H3,(H,14,15)
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PubMed
n/an/an/an/a 520n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation


J Med Chem 50: 1445-8 (2007)


Article DOI: 10.1021/jm070022x
BindingDB Entry DOI: 10.7270/Q2BK1C1Z
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(Homo sapiens (Human))
BDBM50208138
PNG
((+)-acifran | (-)-acifran | 5-Methyl-4-oxo-5-pheny...)
Show SMILES CC1(OC(=CC1=O)C(O)=O)c1ccccc1
Show InChI InChI=1S/C12H10O4/c1-12(8-5-3-2-4-6-8)10(13)7-9(16-12)11(14)15/h2-7H,1H3,(H,14,15)
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Article
PubMed
n/an/an/an/a 4.20E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assay


Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))
BDBM50208138
PNG
((+)-acifran | (-)-acifran | 5-Methyl-4-oxo-5-pheny...)
Show SMILES CC1(OC(=CC1=O)C(O)=O)c1ccccc1
Show InChI InChI=1S/C12H10O4/c1-12(8-5-3-2-4-6-8)10(13)7-9(16-12)11(14)15/h2-7H,1H3,(H,14,15)
Reactome pathway
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CHEMBL
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Article
PubMed
n/an/a 500n/an/an/an/an/an/a



Arena Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Activity at GPR109a (unknown origin) assessed as inhibition of forskolin-stimulated cAMP production


J Med Chem 51: 7653-62 (2008)


Article DOI: 10.1021/jm800896z
BindingDB Entry DOI: 10.7270/Q27D2TZ5
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))
BDBM50208138
PNG
((+)-acifran | (-)-acifran | 5-Methyl-4-oxo-5-pheny...)
Show SMILES CC1(OC(=CC1=O)C(O)=O)c1ccccc1
Show InChI InChI=1S/C12H10O4/c1-12(8-5-3-2-4-6-8)10(13)7-9(16-12)11(14)15/h2-7H,1H3,(H,14,15)
Reactome pathway
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CHEMBL
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Article
PubMed
n/an/an/an/a 160n/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Agonist activity at HCA2 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISA


Bioorg Med Chem 23: 4013-25 (2015)


Article DOI: 10.1016/j.bmc.2015.02.018
BindingDB Entry DOI: 10.7270/Q22N558B
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))
BDBM50208138
PNG
((+)-acifran | (-)-acifran | 5-Methyl-4-oxo-5-pheny...)
Show SMILES CC1(OC(=CC1=O)C(O)=O)c1ccccc1
Show InChI InChI=1S/C12H10O4/c1-12(8-5-3-2-4-6-8)10(13)7-9(16-12)11(14)15/h2-7H,1H3,(H,14,15)
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


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Article
PubMed
n/an/an/an/a 520n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation


J Med Chem 50: 1445-8 (2007)


Article DOI: 10.1021/jm070022x
BindingDB Entry DOI: 10.7270/Q2BK1C1Z
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))
BDBM50208138
PNG
((+)-acifran | (-)-acifran | 5-Methyl-4-oxo-5-pheny...)
Show SMILES CC1(OC(=CC1=O)C(O)=O)c1ccccc1
Show InChI InChI=1S/C12H10O4/c1-12(8-5-3-2-4-6-8)10(13)7-9(16-12)11(14)15/h2-7H,1H3,(H,14,15)
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 500n/an/an/an/an/an/a



Arena Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Activity at GPR109a (unknown origin) assessed as inhibition of forskolin-stimulated cAMP production


J Med Chem 51: 7653-62 (2008)


Article DOI: 10.1021/jm800896z
BindingDB Entry DOI: 10.7270/Q27D2TZ5
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))
BDBM50208138
PNG
((+)-acifran | (-)-acifran | 5-Methyl-4-oxo-5-pheny...)
Show SMILES CC1(OC(=CC1=O)C(O)=O)c1ccccc1
Show InChI InChI=1S/C12H10O4/c1-12(8-5-3-2-4-6-8)10(13)7-9(16-12)11(14)15/h2-7H,1H3,(H,14,15)
Reactome pathway
KEGG

UniProtKB/SwissProt
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DrugBank
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GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 1.30E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at N-terminal HA-tagged GPR109a receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assay


Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(Homo sapiens (Human))
BDBM50208138
PNG
((+)-acifran | (-)-acifran | 5-Methyl-4-oxo-5-pheny...)
Show SMILES CC1(OC(=CC1=O)C(O)=O)c1ccccc1
Show InChI InChI=1S/C12H10O4/c1-12(8-5-3-2-4-6-8)10(13)7-9(16-12)11(14)15/h2-7H,1H3,(H,14,15)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 316n/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Agonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISA


Bioorg Med Chem 23: 4013-25 (2015)


Article DOI: 10.1016/j.bmc.2015.02.018
BindingDB Entry DOI: 10.7270/Q22N558B
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(Homo sapiens (Human))
BDBM50208138
PNG
((+)-acifran | (-)-acifran | 5-Methyl-4-oxo-5-pheny...)
Show SMILES CC1(OC(=CC1=O)C(O)=O)c1ccccc1
Show InChI InChI=1S/C12H10O4/c1-12(8-5-3-2-4-6-8)10(13)7-9(16-12)11(14)15/h2-7H,1H3,(H,14,15)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a



Arena Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production


J Med Chem 51: 7653-62 (2008)


Article DOI: 10.1021/jm800896z
BindingDB Entry DOI: 10.7270/Q27D2TZ5
More data for this
Ligand-Target Pair