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BDBM50208236 1-(5-chloro-1-methyl-1H-indol-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl(methyl)phosphinic acid::CHEMBL374087

SMILES: Cn1cc(C(C(=O)Nc2ccc3ccccc3c2)P(C)(O)=O)c2cc(Cl)ccc12

InChI Key: InChIKey=DUKXGYAXMZVWHC-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50208236   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Chymase


(Homo sapiens (Human))
BDBM50208236
PNG
(1-(5-chloro-1-methyl-1H-indol-3-yl)-2-(naphthalen-...)
Show SMILES Cn1cc(C(C(=O)Nc2ccc3ccccc3c2)P(C)(O)=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C22H20ClN2O3P/c1-25-13-19(18-12-16(23)8-10-20(18)25)21(29(2,27)28)22(26)24-17-9-7-14-5-3-4-6-15(14)11-17/h3-13,21H,1-2H3,(H,24,26)(H,27,28)
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MMDB

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Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human skin chymase


J Med Chem 50: 1727-30 (2007)


Article DOI: 10.1021/jm0700619
BindingDB Entry DOI: 10.7270/Q26W99RF
More data for this
Ligand-Target Pair