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BDBM50209423 1,2-bis(2-fluorophenyl)ethane-1,2-dione::CHEMBL244633

SMILES: Fc1ccccc1C(=O)C(=O)c1ccccc1F

InChI Key: InChIKey=UWQCHLREAXYCBW-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50209423   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Carboxylesterase 2


(Homo sapiens (Human))
BDBM50209423
PNG
(1,2-bis(2-fluorophenyl)ethane-1,2-dione | CHEMBL24...)
Show SMILES Fc1ccccc1C(=O)C(=O)c1ccccc1F
Show InChI InChI=1S/C14H8F2O2/c15-11-7-3-1-5-9(11)13(17)14(18)10-6-2-4-8-12(10)16/h1-8H
NCI pathway
KEGG

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CHEMBL
PC cid
PC sid
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Article
PubMed
55.9n/an/an/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human intestinal carboxylesterase


Bioorg Med Chem 15: 3801-17 (2007)


Article DOI: 10.1016/j.bmc.2007.03.012
BindingDB Entry DOI: 10.7270/Q29G5MGV
More data for this
Ligand-Target Pair
Acyl-CoA: cholesterol acyltransferase (ACAT)


(Homo sapiens (Human))
BDBM50209423
PNG
(1,2-bis(2-fluorophenyl)ethane-1,2-dione | CHEMBL24...)
Show SMILES Fc1ccccc1C(=O)C(=O)c1ccccc1F
Show InChI InChI=1S/C14H8F2O2/c15-11-7-3-1-5-9(11)13(17)14(18)10-6-2-4-8-12(10)16/h1-8H
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
185n/an/an/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human carboxylesterase 1


Bioorg Med Chem 15: 3801-17 (2007)


Article DOI: 10.1016/j.bmc.2007.03.012
BindingDB Entry DOI: 10.7270/Q29G5MGV
More data for this
Ligand-Target Pair
Cholinesterases


(Homo sapiens (Human))
BDBM50209423
PNG
(1,2-bis(2-fluorophenyl)ethane-1,2-dione | CHEMBL24...)
Show SMILES Fc1ccccc1C(=O)C(=O)c1ccccc1F
Show InChI InChI=1S/C14H8F2O2/c15-11-7-3-1-5-9(11)13(17)14(18)10-6-2-4-8-12(10)16/h1-8H
PDB
MMDB

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KEGG

UniProtKB/SwissProt

B.MOAD
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GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>1.00E+5n/an/an/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human BChE


Bioorg Med Chem 15: 3801-17 (2007)


Article DOI: 10.1016/j.bmc.2007.03.012
BindingDB Entry DOI: 10.7270/Q29G5MGV
More data for this
Ligand-Target Pair
Cholinesterases


(Homo sapiens (Human))
BDBM50209423
PNG
(1,2-bis(2-fluorophenyl)ethane-1,2-dione | CHEMBL24...)
Show SMILES Fc1ccccc1C(=O)C(=O)c1ccccc1F
Show InChI InChI=1S/C14H8F2O2/c15-11-7-3-1-5-9(11)13(17)14(18)10-6-2-4-8-12(10)16/h1-8H
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>1.00E+5n/an/an/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human AChE


Bioorg Med Chem 15: 3801-17 (2007)


Article DOI: 10.1016/j.bmc.2007.03.012
BindingDB Entry DOI: 10.7270/Q29G5MGV
More data for this
Ligand-Target Pair