BDBM50209506 CHEMBL266212::N-(2-(4-(4-(3,4-dimethoxybenzyl)piperazin-1-yl)phenylcarbamoyl)phenyl)quinoline-3-carboxamide

SMILES COc1ccc(CN2CCN(CC2)c2ccc(NC(=O)c3ccccc3NC(=O)c3cnc4ccccc4c3)cc2)cc1OC

InChI Key InChIKey=LYPHFRXCVAZTEC-UHFFFAOYSA-N

Data  10 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50209506   

TargetCytochrome P450 2A6(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209506(CHEMBL266212 | N-(2-(4-(4-(3,4-dimethoxybenzyl)pip...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2A6 expressed in insect microsome after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209506(CHEMBL266212 | N-(2-(4-(4-(3,4-dimethoxybenzyl)pip...)
Affinity DataIC50:  2.02E+4nMAssay Description:Inhibition of human CYP3A4 expressed in insect microsome using 7-benzyloxy-4-trifluoromethylcoumarin substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209506(CHEMBL266212 | N-(2-(4-(4-(3,4-dimethoxybenzyl)pip...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2B6 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209506(CHEMBL266212 | N-(2-(4-(4-(3,4-dimethoxybenzyl)pip...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP1A2 expressed in insect microsome after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209506(CHEMBL266212 | N-(2-(4-(4-(3,4-dimethoxybenzyl)pip...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2E1 expressed in insect microsome after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209506(CHEMBL266212 | N-(2-(4-(4-(3,4-dimethoxybenzyl)pip...)
Affinity DataIC50:  1.33E+4nMAssay Description:Inhibition of human CYP2C8 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209506(CHEMBL266212 | N-(2-(4-(4-(3,4-dimethoxybenzyl)pip...)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibition of human CYP2C19 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209506(CHEMBL266212 | N-(2-(4-(4-(3,4-dimethoxybenzyl)pip...)
Affinity DataEC50:  124nMAssay Description:Reversal of P-gp-mediated multidrug resistance to vinblastine in human CEM/VLB500 cells after 3 days by resazurin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209506(CHEMBL266212 | N-(2-(4-(4-(3,4-dimethoxybenzyl)pip...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2D6 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209506(CHEMBL266212 | N-(2-(4-(4-(3,4-dimethoxybenzyl)pip...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CYP2C9 expressed in insect microsome after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209506(CHEMBL266212 | N-(2-(4-(4-(3,4-dimethoxybenzyl)pip...)
Affinity DataIC50:  3.58E+3nMAssay Description:Inhibition of human CYP2E1 expressed in insect microsome using 7-benzyloxyquinoline substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed