BDBM50209591 Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(Atz)]-D-[Aph(Atz)]-Leu-ILys-Pro-DAla-NH2::CHEMBL388156::azaline B

SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc(Nc2nnc(N)[nH]2)cc1)NC(=O)[C@H](Cc1ccc(Nc2nnc(N)[nH]2)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O

InChI Key InChIKey=VLGKQBGBPIVGBX-SIHJNPAHSA-N

Data  4 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50209591   

TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50209591(Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(Atz)]-D-[Aph(...)
Affinity DataIC50:  1.40nMAssay Description:Antagonist activity at rat GnRHR expressed in HEK293 cells assessed as inhibition of GnRH-induced luciferase response by reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50209591(Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(Atz)]-D-[Aph(...)
Affinity DataIC50:  1.36nMAssay Description:Antagonist activity at human GnRHR expressed in HEK293 cells assessed as inhibition of GnRH-induced luciferase response by reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50209591(Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(Atz)]-D-[Aph(...)
Affinity DataKd:  1.58nMAssay Description:Competitive antagonism of GnRH-induced response in the reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50209591(Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(Atz)]-D-[Aph(...)
Affinity DataIC50:  1.40nMAssay Description:Antagonism of GnRH response in HEK293 cells expressing human GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50209591(Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(Atz)]-D-[Aph(...)
Affinity DataIC50:  6.90nMAssay Description:Antagonism of human GnHR receptor, determined in a reporter gene assay in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed