BDBM50210127 CHEMBL3884851

SMILES Cc1c2c(cc(n1)N)OCC/C=C/CCCOc3cc(ccc3Cn4cc(cn4)C(=O)NC2)Cn5cccn5

InChI Key InChIKey=ZVYLYYBRLJOHMS-UHFFFAOYSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50210127   

TargetPlasma kallikrein(Human)
Global Blood Therapeutics

Curated by ChEMBL
LigandPNGBDBM50210127(CHEMBL3884851)
Affinity DataIC50: 2nMAssay Description:Inhibition of human plasma kallikrein using D-Pro-Phe-Arg-pNA as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCoagulation factor XI(Human)
Global Blood Therapeutics

Curated by ChEMBL
LigandPNGBDBM50210127(CHEMBL3884851)
Affinity DataIC50: 3.61E+3nMAssay Description:Inhibition of factor 11a (unknown origin) using S-2366 as substrate incubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
Global Blood Therapeutics

Curated by ChEMBL
LigandPNGBDBM50210127(CHEMBL3884851)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of factor 12a (unknown origin) using D-Pro-Phe-Arg-pNA as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details Article
PubMed
TargetPlasminogen(Human)
Global Blood Therapeutics

Curated by ChEMBL
LigandPNGBDBM50210127(CHEMBL3884851)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of Lys-plasmin (unknown origin) using Tosyl-Gly-Pro-Lys-4-nitranilide as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
Global Blood Therapeutics

Curated by ChEMBL
LigandPNGBDBM50210127(CHEMBL3884851)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of tPA (unknown origin) using Methylsulfonyl-D-Phe-Gly-Arg-pNA as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Global Blood Therapeutics

Curated by ChEMBL
LigandPNGBDBM50210127(CHEMBL3884851)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of factor 10a (unknown origin) using N-Z-D-Arg-Gly-Arg-pNA as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details Article
PubMed
TargetProthrombin(Human)
Global Blood Therapeutics

Curated by ChEMBL
LigandPNGBDBM50210127(CHEMBL3884851)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of alpha-thrombin (unknown origin) using D-Phe-Pip-Arg-pNA as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details Article
PubMed