BDBM50210636 (S)-1-(2-(4-(6-fluoronaphthalen-2-yl)piperazin-1-yl)ethyl)isochroman-6-carboxamide::CHEMBL234449

SMILES NC(=O)c1ccc2[C@H](CCN3CCN(CC3)c3ccc4cc(F)ccc4c3)OCCc2c1

InChI Key InChIKey=LSKWSFUPQIOHOG-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50210636   

TargetSodium-dependent serotonin transporter(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50210636((S)-1-(2-(4-(6-fluoronaphthalen-2-yl)piperazin-1-y...)
Affinity DataKi:  8.10nMAssay Description:Displacement of [3H]citalopram from human 5HT transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50210636((S)-1-(2-(4-(6-fluoronaphthalen-2-yl)piperazin-1-y...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]GR-125743 from human 5HT1D expressed in LM(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50210636((S)-1-(2-(4-(6-fluoronaphthalen-2-yl)piperazin-1-y...)
Affinity DataKi:  704nMAssay Description:Displacement of [3H]raclopride from dopamine D2 receptor in rat caudate membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50210636((S)-1-(2-(4-(6-fluoronaphthalen-2-yl)piperazin-1-y...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]GR-125743 from human 5HT1B expressed in LM(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed