BDBM50214089 5-(4-chlorophenyl)-6-methyl-1-o-tolyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one::CHEMBL246611

SMILES Cc1ccccc1-n1ncc2c1nc(C)n(-c1ccc(Cl)cc1)c2=O

InChI Key InChIKey=ZHNTXQSBMKGLSO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50214089   

TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50214089(5-(4-chlorophenyl)-6-methyl-1-o-tolyl-1H-pyrazolo[...)
Affinity DataIC50:  9.50E+3nMAssay Description:Antagonist activity at human mGluR5 receptor expressed in 132N1 cells assessed as inhibition of glutamate-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50214089(5-(4-chlorophenyl)-6-methyl-1-o-tolyl-1H-pyrazolo[...)
Affinity DataIC50:  350nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in 132N1 cells assessed as inhibition of glutamate-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed