BDBM50214927 (Z)-5-(4-chlorobenzylidene)-10-methoxy-2,2,4-trimethyl-2,4a,5,12a-tetrahydro-1H-chromeno[3,4-f]quinolin-9-ol::CHEMBL391458

SMILES COc1c(O)ccc2O\C(=C/c3ccc(Cl)cc3)C3=C(C=CC4NC(C)(C)C=C(C)C34)c12

InChI Key InChIKey=CRMWXHKNLRRSNA-XKZIYDEJSA-N

Data  1 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50214927   

TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214927((Z)-5-(4-chlorobenzylidene)-10-methoxy-2,2,4-trime...)
Affinity DataKi:  1.70nMAssay Description:Displacement of radiolabeled dexamethasone from glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214927((Z)-5-(4-chlorobenzylidene)-10-methoxy-2,2,4-trime...)
Affinity DataIC50:  12nMAssay Description:Activity at GR assessed as repression of TNFalpha and IL 1beta induced E-selectin responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214927((Z)-5-(4-chlorobenzylidene)-10-methoxy-2,2,4-trime...)
Affinity DataEC50:  43nMAssay Description:Agonist activity at GR by GRE activation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214927((Z)-5-(4-chlorobenzylidene)-10-methoxy-2,2,4-trime...)
Affinity DataIC50: >1.00E+3nMAssay Description:Antagonist activity at GR assessed as inhibition of dexamethasone-induced GRE activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed