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BDBM50219619 CHEMBL248428::N-(3-(4-fluoro-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-5-yl)-4-(6-(2-hydroxyethylamino)pyrimidin-4-ylamino)benzamide

InChI string: InChI=1S/C22H17F4N7O2S/c23-16-6-3-13(9-15(16)22(24,25)26)19-31-21(36-33-19)32-20(35)12-1-4-14(5-2-12)30-18-10-17(27-7-8-34)28-11-29-18/h1-6,9-11,34H,7-8H2,(H2,27,28,29,30)(H,31,32,33,35)

SMILES: OCCNc1cc(Nc2ccc(cc2)C(=O)Nc2nc(ns2)-c2ccc(F)c(c2)C(F)(F)F)ncn1

InChI Key: InChIKey=ZQQCWYBWBQMAOD-UHFFFAOYSA-N

Data: 1 EC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50219619   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombopoietin receptor


(Homo sapiens)
BDBM50219619
PNG
(CHEMBL248428 | N-(3-(4-fluoro-3-(trifluoromethyl)p...)
Show SMILES OCCNc1cc(Nc2ccc(cc2)C(=O)Nc2nc(ns2)-c2ccc(F)c(c2)C(F)(F)F)ncn1
Show InChI InChI=1S/C22H17F4N7O2S/c23-16-6-3-13(9-15(16)22(24,25)26)19-31-21(36-33-19)32-20(35)12-1-4-14(5-2-12)30-18-10-17(27-7-8-34)28-11-29-18/h1-6,9-11,34H,7-8H2,(H2,27,28,29,30)(H,31,32,33,35)
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PC sid
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Similars

AffyNet 
Article
PubMed
n/an/an/an/a 30n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair