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BDBM50219633 4-(6-(azetidin-1-yl)pyrimidin-4-ylamino)-N-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-yl)benzamide::CHEMBL248217

InChI string: InChI=1S/C24H18F4N6OS/c25-21-16(3-1-4-17(21)24(26,27)28)18-12-36-23(32-18)33-22(35)14-5-7-15(8-6-14)31-19-11-20(30-13-29-19)34-9-2-10-34/h1,3-8,11-13H,2,9-10H2,(H,29,30,31)(H,32,33,35)

SMILES: Fc1c(cccc1C(F)(F)F)-c1csc(NC(=O)c2ccc(Nc3cc(ncn3)N3CCC3)cc2)n1

InChI Key: InChIKey=BIXPZICKNFMWJX-UHFFFAOYSA-N

Data: 1 EC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50219633   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombopoietin receptor


(Homo sapiens)
BDBM50219633
PNG
(4-(6-(azetidin-1-yl)pyrimidin-4-ylamino)-N-(4-(2-f...)
Show SMILES Fc1c(cccc1C(F)(F)F)-c1csc(NC(=O)c2ccc(Nc3cc(ncn3)N3CCC3)cc2)n1
Show InChI InChI=1S/C24H18F4N6OS/c25-21-16(3-1-4-17(21)24(26,27)28)18-12-36-23(32-18)33-22(35)14-5-7-15(8-6-14)31-19-11-20(30-13-29-19)34-9-2-10-34/h1,3-8,11-13H,2,9-10H2,(H,29,30,31)(H,32,33,35)
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Article
PubMed
n/an/an/an/a 23n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Bioorg Med Chem Lett 17: 5447-54 (2007)

More data for this
Ligand-Target Pair