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BDBM50219644 CHEMBL248390::N-(5-chloro-4-(4-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-yl)-4-(6-(dimethylamino)pyrimidin-4-ylamino)benzamide

InChI string: InChI=1S/C23H17ClF4N6OS/c1-34(2)18-10-17(29-11-30-18)31-14-6-3-12(4-7-14)21(35)33-22-32-19(20(24)36-22)13-5-8-16(25)15(9-13)23(26,27)28/h3-11H,1-2H3,(H,29,30,31)(H,32,33,35)

SMILES: CN(C)c1cc(Nc2ccc(cc2)C(=O)Nc2nc(c(Cl)s2)-c2ccc(F)c(c2)C(F)(F)F)ncn1

InChI Key: InChIKey=AAIUODNJTNMLJB-UHFFFAOYSA-N

Data: 1 EC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50219644   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombopoietin receptor


(Homo sapiens)
BDBM50219644
PNG
(CHEMBL248390 | N-(5-chloro-4-(4-fluoro-3-(trifluor...)
Show SMILES CN(C)c1cc(Nc2ccc(cc2)C(=O)Nc2nc(c(Cl)s2)-c2ccc(F)c(c2)C(F)(F)F)ncn1
Show InChI InChI=1S/C23H17ClF4N6OS/c1-34(2)18-10-17(29-11-30-18)31-14-6-3-12(4-7-14)21(35)33-22-32-19(20(24)36-22)13-5-8-16(25)15(9-13)23(26,27)28/h3-11H,1-2H3,(H,29,30,31)(H,32,33,35)
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Article
PubMed
n/an/an/an/a 11n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Bioorg Med Chem Lett 17: 5447-54 (2007)

More data for this
Ligand-Target Pair